Unraveling the role of circulating large extracellular vesicles in limphomas

In charge: Dr. Lucia Catani

Scientific activity

The studies published so far on the role of extracellular vesicles (EVs) in lymphomas are primarily concerned with extracellular vesicles (EVs) of small dimensions (S-EVs <150-200 nm).

By contrast, the phenotype/cargo of large EVs (L-EVs; >200-300 nm) from lymphoma patients is still unknown.

Furthermore, how EVs, and in particular L-EVs, reprogram and 'educate' the surrounding microenvironment, and in particular the immune microenvironment, has never been investigated.

Bearing in mind that L-EVs and S-EVs may display different phenotype/cargo, and possibly function, the liquid biopsy in lymphomas is potentially represented by L-EVs and their role as 'biomarkers' and in 'crosstalk' with the immune microenvironment.

Projects

  • Investigating the role of large sized circulating extracellular vesicles in lymphomas (2022)

In charge

Lucia Catani

Assistant professor

Department of Experimental, Diagnostic and Specialty Medicine - Via Massarenti 9, Bologna

+39 051 2143837

+39 051 636 4 037

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team

Filippo Maltoni

PhD Student

Department of Experimental, Diagnostic and Specialty Medicine - Via Massarenti 9, Bologna

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Ghazal Narimanfar

PhD Student

Department of Biomedical and Neuromotor Sciences - Via Massarenti 9, Bologna

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