Precellys Tissue Homogenizer

The Precellys tissue homogenizer (Bertin Instruments), an advanced system for the lysis and disruption of biological samples based on three-dimensional bead-beating technology. This instrument ensures high standardization and reproducibility in pre-analytical preparation, allowing multiple samples to be processed in parallel under strictly controlled conditions. Thanks to the high mechanical energy generated, it is particularly effective in disrupting tough biological matrices, such as fibrous, bone, or muscle tissues, which are typically difficult to process using conventional manual methods.

Main applications:

• Nucleic Acid Extraction (DNA/RNA): Rapid isolation of intact, high-yield genetic material from complex tissues, essential for subsequent genomic and transcriptomic investigations (e.g., qPCR, NGS sequencing).
• Protein Extraction: Deep and efficient cellular lysis that ensures the quantitative recovery of total proteins, fundamental for immunochemical assays (such as Western Blot and ELISA) as well as structural and proteomic studies.
• Metabolite and Drug Isolation: Homogeneous processing for the extraction of small molecules, endogenous compounds, or active pharmaceutical ingredients from biological matrices, supporting pharmacokinetic, toxicological, and metabolomic studies.
• Microbiology and Pathology: Disruption of biofilms, lysis of microorganisms with thick cell walls (such as yeasts, fungi, and spores), and the release of intracellular components for downstream molecular investigations.